HOME: Dr. Lim Siong Meng

Lim Siong Meng

LimSiongMeng

Address & Contact:

Collaborative Drug Discovery Research (CDDR) Lab

FF3-Level 7,
Faculty of Pharmacy,
UiTM Puncak Alam Campus
42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.

Phone 1: +603-3258 4692 (Laboratory)
Phone 2: +603-3258 4727 (Office)

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Research Group

Link to CDDR Lab

Google Scholar

Link to Google Scholar

ResearchGate

Link to ResearchGate

UiTM Pure

Link to UiTM Pure

PRISMa UiTM

Link to PRISMa UiTM

Positions

  • Senior Lecturer Faculty of Pharmacy, UiTM
  • Co-Leader CDDR Lab
  • Head of Internal Audit

Education

  • PhD (Medicine), University of New South Wales (UNSW), Australia, 2013
  • MSc. (Oncology), University of Nottingham, UK, 2003
  • BSc. (Biomedical Sciences), Universiti Putra Malaysia (UPM), 2002

Teaching

  • Applied pharmacology in nursing (MSc)
  • Cancer pharmacotherapeutics (BPharm)
  • Blood and CVS Pharmacotherapeutics (BPharm)
  • Principles of Medical Pharmacology (BPharm)
  • Drug therapy (CVS, GIT, Antimicrobial and Anticancer Chemotherapy) (Diploma)

Activities

  • Committee Member, Malaysian Metabolomics Society (2016-2018)
  • Member, Chevening Alumni of Malaysia (lifetime)

Research Interest

  • Nutraceuticals and natural products (Anticancer, hypocholesterolaemic and neuroprotective potentials)
  • Therapeutic targets (Alzheimer’s disease, cancer and Parkinson's disease)
  • Angiogenesis

Current Postgraduate Students

No.

Postgraduate Student

Degree

Institutions

Year Enrolled

Year End

Main Supervision

1

Muhammad Zaki Ramli

PhD

UiTM

2013

2017

2

Muhamad Zaki Zakaria

MSc

UiTM

2014

2017

Co-Supervision


1

Muhammad Fareez Ismail

PhD UiTM 2013 2017

2

Syamimi Samah

PhD

UiTM

2015

2018

3

Che Nor Adlia Enche Ady

MSc

UiTM

2011

2016

4 Nor Amalina Ahmad MSc UiTM 2012 2017
5 Dayana Sazereen Mohd Hasni MSc UiTM 2012 2017
6 Muhammad Syukri Noor Azman MSc UiTM 2015 2017
7 Fatin Umirah MSc UiTM 2016 2018

On-going Research Grants

No.

Research Project

Source

Begin Year

End Year

Principal Investigator

1

Cheminformatics-driven elucidation of the anti-angiogenecity of F8268

Lestari (UiTM)

2016

2018

2

RhoA targeting by probiotics as strategy to interfere the critical link to major hallmark of Alzheimer's disease

GIP (UiTM)

2016

2017

Co-Investigator


1

IBRO Associate School Workshop

IBRO-APRC

2016

2016

2

Integrative Systematic Biology in Understanding the Cellular and Molecular Mechanisms of Locally Derived Feed Supplements for Poultry

LRGS (MOHE)

2012

2017

3

AD Blood Biomarkers and Pathway Analysis in the Human Subject: an Integrative-OMICS Approach

LRGS (MOHE)

2012

2016

4

Mechanism of Ciproxifan Against Cholinergic Deficit-Induced Neuronal Plasticity via Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway

FRGS (MOHE)

2013

2016

5

Gut Hormones and Anti-inflammatory Pathways in Probiotics-mediated Glycaemic Control and Improved Quality of Life

FRGS (MOHE)

2014

2017

6

Dopaminergic Neuroregeneration In Parkinson’s Disease: Missing Links In Wnt Signalling And Beyond

FRGS (MOHE)

2016

2019

7

Role Of D-Amino Oxidase Inhibitors As Potential Drugs In The Treatment Of Alzheimer’s Disease: A Proteochemometric Modelling And In Vivo Study

FRGS (MOHE)

2016

2019

8

Deciphering the inter-relationships between self-efficacy, glycaemic control and quality of life among type 2 diabetes patients

Lestari (UiTM)

2016

2018

9

Unravelling the neuroprotective effects of probiotics fermented in soymilk

iRAGS (UiTM)

2015

2017

Selected Publications

  1. Chin Fen Neoh, Chiau Ming Long, Siong Meng Lim, Kalavathy Ramasamy, Suzana Shahar, Abu Bakar Abdul Majeed (2016) Medication use and adherence among multi-ethnic community dwelling older adults in Malaysia. Geriatrics & Gerontology International, DOI: 10.1111/ggi.12849 (IF = 2.188/ ISI/ Q1)
  2. Ismail M. Fareez, Siong Meng Lim, Fei Tieng Lim, Rakesh K. Mishra and Kalavathy Ramasamy (2016) Microencapsulation of Lactobacillus SP. Using Chitosan-Alginate-Xanthan Gum-?-Cyclodextrin and Characterization of its Cholesterol Reducing Potential and Resistance Against pH, Temperature and Storage. Journal of Food Process Engineering, DOI: 10.1111/jfpe.12458 (IF = 0.830/ ISI/ Q2)
  3. Sazereen Md Hasni Dayana, Siong Meng Lim, Ai Vyrn Chin, Maw Pin Tan, Philip Jun Hua Poi, Shahrul Bahyah Kamaruzzaman, Abu Bakar Abdul Majeed, Kalavathy Ramasamy (2016) Peripheral cytokines, C-X-C motif ligand10 and interleukin-13, are associated with Malaysian Alzheimer's disease. Geriatrics & Gerontology International, DOI: 10.1111/ggi.12783 (IF = 2.188/ ISI/ Q1)
  4. Syamimi Samah, Kalavathy Ramasamy, Siong Meng Lim, Chin Fen Neoh (2016) Probiotics for the management of Type 2 Diabetes Mellitus: a systematic review and meta-analysis. Diabetes Research and Clinical Practice, 118, 172-182 (IF = 2.538/ ISI/ Q1)
  5. Aakash Deep, Pradeep Kumar, Balasubramanian Narasimhan, Lim Siong Meng, Kalavathy Ramasamy, Rakesh Kumar Mishra, Vasudevan Mani (2016) Synthesis, Antimicrobial and Anticancer Evaluation of 2-Azetidinones Clubbed with Quinazolinone. Pharmaceutical Chemistry Journal, 50 (1), 24 – 28 (IF = 0.452/ ISI/ Q3)
  6. Aakash Deep, Pradeep Kumar, Balasubramanian Narasimhan, Siong Meng Lim, Kalavathy Ramasamy, Rakesh Kumar Mishra and Vasudevan Mani (2016) 2-Azetidinone Derivatives: Synthesis, Antimicrobial, Anticancer Evaluation And Qsar Studies. Acta Poloniae Pharmaceutica, 73 (1), 65 – 78 (IF = 0.74/ ISI/ Q2)
  7. Aakash Deep, Pradeep Kumar, Balasubrmanian Narasimhan, Kalavathy Ramasamy, Siong Meng Lim, Vasudevan Mani and Rakesh Kumar Mishra (2016) Synthesis, Antimicrobial, Anticancer Evaluation And Qsar Studies Of Thiazolidin-4-One Derivatives, Acta Poloniae Pharmaceutica, 73 (1), 93 – 106 (IF = 0.74/ ISI/ Q2)
  8. Nurhanisah Sejari, Kamaria Kamaruddin, Kalavathy Ramasamy, Siong Meng Lim, Chin Fen Neoh, Long Chiau Ming (2016) The immediate effect of traditional Malay massage on substance P, inflammatory mediators, pain scale and functional outcome among patients with low back pain: Study protocol of a randomised controlled trial. BMC Complementary and Alternative Medicine, 16:16 DOI: 10.1186/s12906-016-0988-1 (IF = 2.020/ ISI/ Q1)
  9. Azzeme Harun, Sharmili Vidyadaran, Siong Meng Lim, Anthony L J Cole and Kalavathy Ramasamy (2015) Malaysian endophytic fungal extracts-induced anti-inflammation in lipopolysaccharide-activated BV-2 microglia is associated with attenuation of NO production and, IL-6 and TNF-? expression. BMC Complementary and Alternative Medicine, 15, 166 (IF = 2.020/ ISI/ Q1)
  10. Ismail M. Fareez, Siong Meng Lim, Rakesh K. Mishra and Kalavathy Ramasamy (2015) Chitosan coated alginate-xanthan gum bead enhanced pH and thermotolerance of Lactobacillus plantarum LAB12. International Journal of Biological Macromolecules, 72 (2015), 1419-1428. (IF = 2.858/ ISI/ Q2)
  11. R K Mishra, K Ramasamy, S M Lim, M F Ismail and A B A Majeed (2014) Antimicrobial and in vitro would healing properties of novel clay based bionanocomposite files. Journal of Materials Science: Materials in Medicine, 25 (8), 1925-1939. (IF=2.379/ ISI/ Q1)
  12. Pooja Rohilla, Aakash Deep, Manju Kamra, Balasubramanian Narasimhan, Kalavathy Ramasamy, Vasudevan Mani, Rakesh Kumar Mishra, Siong Meng Lim (2014) Synthesis, antimicrobial and anticancer evaluation of N’-(substituted benzylidene)-2-(benzo[d]oxazol-3(2H)-yl)aceto hydrazine derivatives. Drug Research, 64, doi: 10.1055/s-0034-1368720 (IF=0.559/ ISI/ e-Pub ahead of print/ Q3)
  13. Nurul Aqmar M.N. Hazalin, Siong Meng Lim*, Anthony L.J. Cole, Abu Bakar A. Majeed and Kalavathy Ramasamy (2013) Apoptosis induced by desmethyl-lasiodiplodin is associated with upregulation of apoptotic genes and downregulation of monocyte chemotactic protein-3. Anti-Cancer Drugs, 24 (8), 852-861 (IF = 1.891/ ISI/ *Joint First Authorship/ Q1)
  14. Hazalin, N A, Ramasamy, K, Lim, S M, Cole, A L, Majeed, A B. (2012) Induction of apoptosis against cancer cell lines by four ascomycetes (endophytes) from Malaysian rainforest. Phytomedicine, 19 (7), 609-617 (IF = 2.972/ ISI/ Q1)
  15. Harun A, Johari James RM, Lim SM, Abdul Majeed AB, Cole AL, Ramasamy K (2011) BACE1 inhibitory activity of fungal endophytic extracts from Malaysian medicinal plants. BMC Complementary and Alternative Medicine, 11 (1), 79 (IF = 2.08/ ISI/ Q1)
  16. Kalavathy Ramasamy, Siong Meng Lim, Hamidah Abu Bakar, Noorliana Ismail, Maria Suhana Ismail, Muhamad Fuad Ali, Jean Frederic Faizal Weber, Anthony L. J. Cole (2010) Antimicrobial and Cytotoxic Activities of Malaysian Endophytes. Phytotherapy Research, 24 (5), 640-643 (IF = 2.068/ ISI/ Q2)
  17. Nurul Aqmar, M.N.H., Kalavathy, R., Lim, S.M., Ibtisam Abdul Wahab, Weber, J.F.F. and Cole, A.L.J., Abu Bakar Abdul Majeed (2009) Cytotoxic and antimicrobial activities of endophytic fungi isolated from plants at the National Park Pahang. BMC Complementary and Alternative Medicine 9, 46 (IF = 2.08/ ISI/ Q1)

Book/Book Chapter

  1. Siong Meng Lim, Muhammad Zaki Bin Ramli, Nor Amalina Ahmad, Vasudevan Mani, Abu Bakar Abdul Majeed and Kalavathy Ramasamy (2015) Probiotics and Neuroprotection. In: Colin R Martin and Victor R Preedy (eds) Diet and Nutrition in Dementia and Cognitive Decline. Elsevier Inc., CA., 859-868
  2. Vasudevan Mani, Aliya Ahmad, Kalavathy Ramasamy, Siong Meng Lim, Abu Bakar Abdul Majeed (2015) Murraya koenigii leaves and usage in dementia. In: Colin R Martin and Victor R Preedy (eds) Diet and Nutrition in Dementia and Cognitive Decline. Elsevier Inc., CA., 1039-1048
  3. Ramasamy, K., Siong Meng, L., Abdul Wahab, I., Hamzah, M. K. and Abdul Majeed, A. B. (2012). Bioactive endophytic metabolites of selected plants in Taman Negara National Park. In M. N. Suratman, M. S. Daim, H. R. Singh & N. H. Ismail (Eds.), Taman Negara: towards biodiversity conservation and sustainability (pp. 3-12). Shah Alam: UiTM Press.

Selected Awards

  1. Diamond Award. N. A. M. Syukri, R. M. Zaki, I. M. Fareez, S. M. Lim and K. Ramasamy (2016) G2BTM: Gut-Brain Revitalized! Invention, Innovation and Design Expo 2016, DATC, UiTM Shah Alam
  2. Gold Award. N. A. M. Syukri, R. M. Zaki, I. M. Fareez, S. M. Lim and K. Ramasamy (2016) G2BTM: Gut-Brain Revitalized! Invention, Innovation and Design Expo 2016, DATC, UiTM Shah Alam
  3. Diamond Award. Z. M. Zaki, N. N. Ban, K. Ramasamy, C. O. Leong and S. M. Lim (2015) ActiPep: A precious gift from nature. Invention, Innovation and Design Expo 2015, DATC, UiTM Shah Alam
  4. Gold Award. Z. M. Zaki, N. N. Ban, K. Ramasamy, C. O. Leong and S. M. Lim (2015) ActiPep: A precious gift from nature. Invention, Innovation and Design Expo 2015, DATC, UiTM Shah Alam
  5. Gold Award. N. S. Rahim, S. M. Lim, V. Mani, N. A. Hazalin and K. Ramasamy (2015) VCoil: Guardian of your brain. Invention, Innovation and Design Expo 2015, DATC, UiTM Shah Alam
  6. Bronze Award. SMH Dayana, SM Lim, MP Tan, AV Chin, PJH Poi, K Sharul, ABA Majeed, K Ramasamy (2015) ADKin: Make that difference in your life with just a drop of blood. Invention, Innovation and Design Expo 2015, DATC, UiTM Shah Alam
  7. Silver Medal. Z. M. Zaki, N. N. Ban, K. Ramasamy, C. O. Leong and S. M. Lim (2015) ActiPep: A precious gift from nature. The 14th International Conference and Exposition on Inventions by Institutions of Higher Learning (PECIPTA 2015)?Kuala Lumpur Convention Centre, Malaysia
  8. Best Presentation. Sazereen Md Hasni Dayana, Siong Meng Lim, Ai Vyrn Chin, Maw Pin Tan, Philip Jun Hua Poi, Shahrul Bahyah Kamaruzzaman, Abu Bakar Abdul Majeed, Kalavathy Ramasamy (2015) CXCL10 And CXCR3 Mediate Neuroinflammation In Alzheimer’s Disease Through STAT, NF?B, Notch1 AND SP1. I-Sihat 2015 Post Conference Symposium: Ageing in Malaysia – from Molecules to Community, 13 August 2015, Institut Latihan Dewan Bandaraya (IDB), Kuala Lumpur.
  9. 2nd runner up (poster presentation). R. M. Zaki, K. Ramasamy and S. M. Lim (2014) RhoA targeting by Lactobacilli as strategy to interfere the critical link to major hallmark of Alzheimer’s disease. The 3rd International Postgraduate Conference on Pharmaceutical Science (iPoPS 2014), Faculty of Pharmacy, UiTM Puncak Alam, Malaysia
  10. Silver Medal. Nor Amalina Ahmad, Muhamad Fareez Ismail, Lim Siong Meng and Kalavathy Ramasamy (2014) AD-Caps: When gut-brain connects. Malaysia Technology Expo 2014, PWTC, Kuala Lumpur.
  11. Silver medal. R. M. Zaki, Ismail M. Fareez, K. Ramasamy and S. M. Lim (2014) Stay healthy, stay Rho-buzz. Invention, Innovation and Design Expo 2014, DATC, UiTM Shah Alam
  12. Bank Islam Malaysia special award. Nor Amalina Ahmad Alwi, Muhamad Fareez Ismail, Kalavathy Ramasamy, Lim Siong Meng, Rakesh Mishra, Vasudevan Mani and Abu Bakar Abdul Majeed (2013) AD-Caps: When gut-brain connects. IIDEX13-SE Innovateur Wannabe!, Dewan Sri Budiman & Anjung Sri Budiman (Annex), UiTM Shah Alam.
  13. Best poster award. Nor Amalina Ahmad Alwi, Muhamad Fareez Ismail, Kalavathy Ramasamy, Lim Siong Meng, Rakesh Mishra, Vasudevan Mani and Abu Bakar Abdul Majeed (2013) AD-Caps: When gut-brain connects. IIDEX13-SE Innovateur Wannabe!, Dewan Sri Budiman & Anjung Sri Budiman (Annex), UiTM Shah Alam.
  14. Category B (Champion). Nor Amalina Ahmad Alwi, Muhamad Fareez Ismail, Kalavathy Ramasamy, Lim Siong Meng, Rakesh Mishra, Vasudevan Mani and Abu Bakar Abdul Majeed (2013) AD-Caps: When gut-brain connects. IIDEX13-SE Innovateur Wannabe!, Dewan Sri Budiman & Anjung Sri Budiman (Annex), UiTM Shah Alam.
  15. Best oral presentation award. Nor Amalina Ahmad, Lim Siong Meng, Vasudevan Mani, Abu Bakar Abdul Majeed and Kalavathy Ramasamy (2013) Lactobacillus probiotic-induced neuroprotection in transgenic mice with Alzheimer’s disease was mediated, in part, through cholinergic and antioxidative pathways. The 3rd International Symposium on Probiotics and Prebiotics: Microbiome, Gut-Brain Axis in Health and Disease - Mechanism, Function and Regulation, Sari Pan Pacific Hotel, Jakarta.
  16. Best poster presentation award. Hanum Ya’akub, Lim Siong Meng, Vasudevan Mani and Kalavathy Ramasamy (2013) Lactic acid bacteria down-regulating pro-inflmmatory cytokines in DSS-induced colitis mice model. The 2nd International Postgraduate Conference on Pharmaceutical Science (iPoPS 2013), Faculty of Pharmacy, UiTM Puncak Alam, Malaysia.
  17. Gold Medal. Mohd Fareez Ismail, Lim Siong Meng, Kalavathy Ramasamy, Rakesh Mishra, Vasudevan Mani and Abu Bakar Abdul Majeed (2013) Capspro: Thermo- and pH-responsive microspheres with enhanced probiotic stability and targeted delivery in human gut. Invention, Innovation and Design Expo 2013, DATC, UiTM Shah Alam.
  18. The University of Western Sydney School of Medicine Award for the best student presentation at the 2012 Australian Society for Medical Research NSW Annual Scientific Meeting, Australian Technology Park, Redfern.
  19. Second runner up of the St George Clinical School Postgraduate 2012 Three Minute Thesis Competition.
  20. 2nd Prize for Oral Presentation. S. M. Lim, J. Perdomo, P. Galettis and M. Links (2011) RhoA inactivation: a potential new mechanism for the antiangiogenic effect of paclitaxel. The St George and Sutherland Hospital Mediacl Research Symposium, The St George Bank Auditorium, Sydney
  21. Judges’ Choice of the 2011 Faculty of Medicine 3 Minute Thesis Competition and Finalist of the 2011 UNSW Interfaculty 3 Minute Thesis Competition

Our Address

Level 11, FF1 Building,
Faculty of Pharmacy, UiTM Puncak Alam Campus
Bandar Puncak Alam
Selangor
42300
MALAYSIA

Tel: +603-32584645
Fax: +603-32584602

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