HOME: Dr. Nurhuda Manshoor

Nurhuda Manshoor

nurhuda

Name: Nurhuda Manshoor

Address: Level 9, FF3, Universiti Teknologi MARA Selangor, 42300 Bandar Puncak Alam, Selangor

Email Address: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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Phone Number: 03-32584715

Fax: 03-32564602

Research Group

Atta-ur-Rahman Institute for Natural Products Discovery

Google Scholar

https://scholar.google.com/citations?user=ozJeqHkAAAAJ&hl=en

PRISMa UiTM

http://prisma.uitm.edu.my/prisma/?doit=DirectoryStafByIdDetail&staffid=Vmtaa2QxWnRWbFZXVkZaT1lYcHNSbFl4YUc1TlZUbFNVRlF3UFE9PQ

ResearchGate

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Current Positions

Senior Lecturer

Academic Qualifications

PhD (Pharmaceutical Chemistry) UiTM, 2011

Master (Natural Product Chemistry) UKM, 2003

Bachelor Degree (Chemistry) UM, 2000

Teaching

Pharmaceutical Organic Chemistry

Pharmaceutical Analysis

Pharmacognosy

Research Interest/s

Phytochemistry:

a)            Chemistry of Dipterocarpaceous plants: oligostilbenes and other phenolic compounds.

b)            Development of modern methodologies in phytochemistry: Plants from selected families are studied for the isolation of new compounds through the application of modern approaches to the isolation of plant secondary metabolites without generation of artefacts. These include extensive usage of HPLC, LC-MS, CPC, and others.

Dereplication of natural products:

We are interested in developing dereplication strategy for rapid identification of closely related compounds in complex mixture. The compounds of interest are identified directly from a crude mixture by introducing the plant crude extract into the LC-MSn system. The fragmentation patterns are compared with those of anticipated pure compounds previously recorded and store in a database. Efforts are on developing a highly automated platform.

Metabolomic fingerprinting:

We develop and validate sets of procedure for fast identification of plant species based on mass spectrometric data. This requires an on-line hyphenation of HPLC and MS to record mass data of all plant extracts and chemometric application for data analyses. This analysis will highlight the correlations between plants species regardless their geographical origin, surrounding vegetation, altitute and/or other parameter(s).

Research Related Activities

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Publications

SELECTED PUBLICATION

Syamimi Hamid, Rohaity Ramli, Nurhuda Manshoor (2016). Resolving Co-eluted Oligostilbenes using Recycling High Performance Liquid Chromatography (R-HPLC). Australian Journal of Basic and Applied Sciences, 10(16), 111-116.

Fatin Nur Afiqah M R, Rohaity Ramli, Nurhuda Manshoor (2016). Development of RP-HPLC Conditions for Separation of Oligostilbenes in 12 Dipterocarpaceae Crude Extracts. International Journal of Pharmacognosy and Phytochemical Research, 8(12), 1929-1934

Nurhuda Manshoor, Mohd F. Fathil, Muhammad H. Jaafar, Mohd A. S. A. Jalil (2016). Liquid chromatography-mass spectrometry dereplication strategy for isolation of oligostilbenes. International Journal of Applied Chemistry, 12 (2), 121-128.

Nursyaza Husna Shaharuddin, Nor Hadiani Bte Ismail, Nurhuda Binti Manshoor, Fatimah Binti Salim, Rohaya Binti Ahmad (2016). Chemical profiling and identification of alkaloids and flavonoids in Uncaria lanosa var. ferrea via UHPLC-ORBITRAP MS. Malaysian Journal of Analytical Sciences, 20 (2) 318-323.

Rohaity Ramli, Nor Hadiani Ismail, Nurhuda Manshoor (2015). Identification of oligostilbenes from Dipterocarpus semivestitus through dereplication technique. Jurnal Teknologi, 77 (2), 85–88.

Nurhuda Manshoor and Jean-Frédéric F. Weber (2015). Mass Spectrometric Analysis for Discrimination of Diastereoisomers. Mass Spectrometry Letters, 6 (4), 99-104.

Nurhuda Manshoor and Jean-Frédéric F. Weber (2015). Mass Fragmentation Patterns as Fingerprints for Positive Identification of Polyphenolic Compounds in a Crude Extract Mass Spectrometry Letters, 6 (4), 105-111.

Nurhuda Manshoor, Aizam Ekhmal, Qamarusy Syazwan, Mohd Shafarin, Norizan Ahmat (2015). Mass fragmentation patterns as fingerprints in identification of known oligostilbenes in dryobalanops spp. Extracts. International Journal of Pharmacognosy and Phytochemical Research, 7(6), 1147-1152.

Bayach, I., Manshoor, N., Sancho-García, J.C., Choudhary, M. I., Trouillas, P., Weber, J. F. (2015). Oligostilbenoids from the Heartwood of N. Heimii: Role of Non-Covalent Association in their Biogenesis. Chemistry-An Asian Journal, 10, 198-211.

Siti Azima, A. M., Noriham, A. and Manshoor, N. (2014). Anthocyanin content in relation to the antioxidant activity and colour properties of Garcinia mangostana peel, Syzigium cumini and Clitoria ternatea extracts. International Food Research Journal, 21(6): 2369-2375.

Nurhuda Manshoor, Ratni Suriyani Jalal and Jean-Frederic Faizal Weber (2014). Dereplication of closely related diastereoisomers. The Polyphenol Communication, 657-658.

Siti Fatimah Wahid, Che Puteh Osman, Nor Hadiani Ismail, Ratni Suriyani Jalal and Nurhuda Manshoor (2013). Distinguishing Isomeric Anthraquinone by LC-MS. Global Journal of Pharmacology, 7 (4): 479-485.

Nurhuda Manshoor, Ratni Suriyani Jalal, Nur Saiful Irwan Muhamad, Muhammad Sufi Neemad and Rasadah Mat Ali (2013). Rapid Identification of Oligostilbenes in Two Shorea Species. World Applied Sciences, Journal 21 (10): 1540-1545.

Siti Y.M. Subki, Jamia A. Jamal, Khairana Husain and Nurhuda Manshoor (2013). Characterisation of leaf essential oils of three Cinnamomum species from Malaysia by gas chromatography and multivariate data analysis. Pharmacognosy Journal, 5, 22-29.

Nurhuda Manshoor and Jean-Frederic Faizal Weber (2013). Ampelopsin H, a Pallidol Derivative Oligostilbene. Science Letters, Vol 7, No 2,11–15.

Siti Azima, A.M., Noriham, A. and Nurhuda, M. (2013). Antioxidant Activities of Syzygium cumini and Ardisia elliptica in relation to their estimated phenolic compositions and chromatic properties. International Journal of Bioscience, Biochemistry and Bioinformatics, 3(4), 314-317.

A. Wibowo, N. Ahmat, A.S. Hamzah, A.L.M. Low, S.A.S. Mohamad, H.Y. Khong, A.S. Sufian, N. Manshoor, H. Takayama (2012). Malaysianol B, an oligostilbenoid derivative from Dryobalanops lanceolata. Fitoterapia. 83 (8), 1569-1575.

Noviany, Hasnah Osman, Wong Keng Chong, Khalijah Awang and Nurhuda Manshoor (2012). Isolation and Characterisation of l,l’-binaphthalene-2,2’-diol, A New Biaryl Natural Product from Sesbania grandiflora Root. Journal of Basic & Applied Sciences. 8 (1), 253-256.

Weesam Al-Rashidi, Nur Nadrah Mat Supri and Nurhuda Manshoor (2011). Cytotoxic activities of crude extract from Costus malortieanus (Costaceae). American-Eurasian Journal of Toxicological Sciences. 3 (2), 63-66.

Julius Kulip, Lam Nyee Fan, Nurhuda Manshoor, Avelinah Julius, Idris Mohd. Said, Johnny Gisil, Julianah A. Joseph, Welly Frederick Tukin Ahmad (2010). Medicinal plants in Maliau Basin, Sabah, Malaysia. Journal of Tropical Biology and Conservation. 6, 21-33.

ARTICLE IN PROCEEDING

Nurhuda Manshoor, Mohd Fazirulrahman Fathil, Muhammad Hakim Jaafar, Mohd Amirul S. A. Jalil (2015). Separation and Purification of Oligostilbenes Using HPLC with Dereplication Strategy. XIII International Conference on Separation and Purification Technology, Barcelona, Spain, 1466-1469.

Nurhuda Manshoor, Antonio Azzollini (2015). Development and validation of an high throughput metabolomic strategy to reveal fungal interspecies communication. International Conference on Natural Products 2015, 24-25 March 2015, Johor Bahru, 69.

Ratni Suriyani Jalal, Nurhuda Manshoor (2015). Ion trap LC-MS approach in characterization of oligostibenes from Neobalanocarpus heimii. International Conference on Natural Products 2015, 24-25 March 2015, Johor Bahru, 143-144.

Rohaity Ramli and Nurhuda Manshoor, Antonio Azzollini (2015). Identification of oligostilbenes from Dipterocarpus semivestitus through dereplication technique. International Conference on Natural Products 2015, 24-25 March 2015, Johor Bahru, 114.

Siti Fatimah Wahid and Nurhuda Manshoor, Antonio Azzollini (2015). Oligostilbenes in stemwood of multiple Dipterocarpaceae species. International Conference on Natural Products 2015, 24-25 March 2015, Johor Bahru, 156-157.

Rohaity Ramli and Nurhuda Manshoor. (2014). Dereplication approach on resveratrol oligomers from Dipterocarpus semivestitus. Proceedings of The International Postgraduate Conference on Pharmaceutical Sciences (iPoPS), Malaysia.

Siti Fatimah Wahid and Nurhuda Manshoor. (2014). Identification of oligostilbenes in methanol extract of Hopea sp. By tandem LC-MS. Proceedings of The International Postgraduate Conference on Pharmaceutical Sciences (iPoPS), Malaysia.

Jalal, R.S., Ayub, A.E.E., Shafie, M.S., Bahrin, Q.S.K., Manshoor, N. and Ahmat, N. (2013). Rapid identification of oligostilbenes in Dipterocarpaceae crude extract. Proceedings of International Conference on Natural Products, Malaysia.

Research Grants

AS PROJECT LEADER

(2010-2012)        LC-MS/MS Approaches to Characterize Oligostilbenes Directly from Crude Extract Mixtures

(2010-2013)        Use of Ion Trap MS as a Tool to Identify Closely Related Polyphenols from a Crude Extract

(2011-2013)        LC-MS Approach in Characterization of Oligostilbenes Directly from the Crude Mixture of Neobalanocarpus heimii Methanolic Extract

(2012-2014)        Fast Analysis of Wood Extractives for Authentication of Plant Species

(2012-2014)        Resveratrol-based oligomeric polyphenols from Dipterocarpus semivestitus (Dipterocarpaceae)

(2013-2014)        Scientific Expedition to Svalbard Island

(2013-2015)        Mass spectra deconvolution as dereplication strategy for rapid secondary metabolite identification

(2015-2017)        Unraveling the enzymes involved in dimerization of resveratrol.

AS PROJECT MEMBER

(2011)   Linkage Development with Limoges University (France) For Quantum Mechanics to Solve Stilbene Dimerisation Determinism

(2012-2014)        Correlation between NMR Metabolomics and In Vivo Mechanism of Action of Antifungal Agents

(2012-2014)        Further Phytochemical Studies of Malaysian Uncaria via LC-MS-MS Dereplication Strategies

(2013-2014)        Exploration of Arctic Secondary Metabolomes

(2013-2015)        Correlation of Metabolite Profile of Ficus Deltoidea Varieties to Their In Vitro X Glucosidase Inhibitory Activity

(2013-2015)        Understanding of Methyl Jasmonate Influence on Synthesis of Kinsenoside in Anoetochilus formosanus in vitro Cultures

(2013-2015)        Phytochemistry Studies on Root of Centella asiatica

(2015-2017)        Elucidating of binding mechanism of a-glucosidase inhibitors using a combined molecular dinamics, STD-NMR and CORCEMA-STD

Awards

2016 Matsumae Fellowship (Tokushima Bunri University, Japan)

2014 Postdoctoral Fellowship (University of Geneva, Switzerland))

Postgraduate Students

POSTGRADUATE SUPERVISION (GRADUATED)

1.            Ratni Suriyani Jalal (MSc)

2.            Siti Nursarah Zubir (MSc)

3.            Yusnita Alwia Binti Yusof (MSc)

               

POSTGRADUATE SUPERVISION (ON-GOING)

1.            Siti Azima Abdul Muttalib (PhD)

2.            Noraini Kasim (PhD)

3.            Fauziahanim Zakaria (PhD)

4.            Rohaity Ramli (MSc)

5.            Fatimawati Lambuk (MSc)

6.            Shahmeen Alias (MSc)

7.           Mohd Yusrie bin Mohd Yunus (MSc)

Undergraduate Final Year Projects

Name:

Year:

Research Title:

Our Address

Level 11, FF1 Building,
Faculty of Pharmacy, UiTM Puncak Alam Campus
Bandar Puncak Alam
Selangor
42300
MALAYSIA

Tel: +603-32584645
Fax: +603-32584602

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