HOME: Prof. Dr. Jean-Frederic Faizal Weber

Jean-Frederic Faizal Weber

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Prof. Dr. Jean-Frédéric F. WEBER

Atta-ur-Rahman Institute for Natural Product Discovery
Level 9 FF3 Building
Faculty of Pharmacy
UiTM Puncak Alam Campus
43600 Bandar Puncak Alam, Selangor. Malaysia

Phone: +603-3258 4686
Email 1: 
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 Microbial Metabolite Research Group

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 Link to Prisma UiTM Publication Database

Positions

  • Fellow, Atta-ur-Rahman Institute for Natural Product Discovery, UiTM
  • Professor, Faculty of Pharmacy, UiTM

Education

  • PhD (Phytochemistry), University of Angers (France), 1988
  • MSc. Pharmacochemistry of Substances of Natural Origin, 1984
  • BPharm (Hons) Pharmacy, University of Reims (France), 1981

Teaching

  • Pharmaceutical Chemistry (Medicinal Chemistry, Pharmaceutical Analysis, Pharmacognosy)

Activities

  • Malaysian Natural Product Society (MNPS), Member
  • Malaysian Society of Toxicology (MySOT), EXCO member
  • Malaysian Society of Metobolomics (MyMS), Auditor
  • Groupe Polyphenols, Member

Research Interest

  • Chemistry of natural products
  • Drug discovery from microbial (especially fungal) resources,
  • Fast dereplication of natural extracts

 

Research Group/Collaborators

No.

Members/Collaborators

Status

Affiliation

1

Dr. Sadia Sultan

Collaborator

Atta-ur-Rahman Institute for Natural Product Discovery /Faculty of Pharmacy, UiTM

2

Dr Syed Adnan Ali Shah

Collaborator

Atta-ur-Rahman Institute for Natural Product Discovery /Faculty of Pharmacy, UiTM

3

Dr Anouar El-Hassane

Post-Doctoral Scholar

Atta-ur-Rahman Institute for Natural Product Discovery, UiTM

 

Current Postgraduate Students

No.

Name

Degree

Institutions

Year Enrolled

Year End

Main Supervisor

1

Ummu Iffah Binti Muzakir

MSc

UiTM

2011

2013

2

Rohani Binti Rahim

MSc

UiTM

2012

2014

3

Siti Nur Sarah Binti Zubir

MSc

UiTM

2012

2014

4

Fatmawati Lembuk

MSc

UiTM

2012

2014

5

Yusnita Alwia Yusof

MSc

UiTM

2013

2015

6

Salwa Mohammed Raweh Abdullah Al Fakeer Fakeey

PhD

UiTM

2008

2013

7

Zuhra Basher

PhD

UiTM

2010

2014

8

Leila Hilout

PhD

UiTM

2011

2014

9

Siti Hajar Sadiran

PhD

UiTM

2012

2014

10

Ahmed Ibrahim Mohamed Ibrahim

PhD

UiTM

2012

2015

11

Muhammad Shuhairi Bin Ahmad Sabri

PhD

UiTM

2012

2014

Co-Supervisor

1

Ratni Suriyani Jalal

MSc

UiTM

2009

2013

2

Mohd Zaimi Mohd Noor

MSc

UiTM

2010

2013

3

Nurul Hamiyah Binti Abd Ghani

MSc

UiTM

2011

2013

4

Normahanim Binti Hassan

MSc

UiTM

2012

2014

5

Hafizan Bin Chaming

MSc

UiTM

2012

2014

6

Sharifah Nurfazilah Binti Wan Yusop

MSc

UiTM

2012

2014

7

Richard Muhammad Johari James

PhD

UiTM

2009

2013

8

Imene Bayach

PhD

U. Limoges

2011

2014

 

On-going Research Grants

No.

Research Project

Source

Begin Year

End Year

Principal Investigator

1

Quantum mechanics to solve stilbene dimerisation determinism

FRGS (MOHE)

2011

2013

Co-Investigator

1

Activation of insulin signalling pathway by endophytic pyrones

ERGS

2011

2013

2

Molecular mechanisms for improvement of cognitive parameters and ammelioration of ß-amyloid production in senescence-accelerated mice by fraction 7 of Polygonum minus (Polygonaceae).

FRGS

2012

2014

3

Correlation between NMR metabolomics and in vivo mechanism of action of antifungal agents.

FRGS

2012

2014

4

Dereplication approach for identification of biotransformed products of anthraquinone crude extract.

ERGS

2012

2014

 

Completed Research Grants

No.

Research Project

Source

Begin Year

End Year

Principal Investigator

1

Studies in biosynthesis in the oligostilbenoid field - Biomimetically patterned syntheses leading to novel oligostilbenoid dimers

MOSTI / SAGA

2005

2008

2

Design, synthesis and pharmacological properties of styryl derivative and their oligomers (Co-, then Principal Investigator).

MOSTI / Biotek

2007

2009

Co-Investigator

1

Malaysian endophytes for the development of new green chemistry reactions and syntheses (Co-Researcher).

Mosti / Science Fund

2008

2010

2

LC-MS/MS approaches to characterize oligostilbenes directly from complex crude extract mixtures (Co-Researcher).

FRGS

2010

2012

 

Publications

Plants of New Caledonia Part 103. Alkaloids of Litsea lecardii

J.-F. Weber, J. Bruneton and J. Pusset.

Planta Medica, 1986, 52 (1), 74-75.

(Scopus indexed; IF2012 = 2.348; ISSN: 0032-0943; DOI: 10.1055/s-2007-969081)

 

Bioproduction d'alcaloïdes pyridocarbazoliques antitumoraux par des cultures cellulaires d'Ochrosia elliptica Labill. (Bioproduction of antitumoral pyridocarbazolic alkaloids by cell cultures of Ochrosia elliptica Labill.)

J.-F. Weber, J. Garnier, T.T.H. Tinh and C. Viel.

Plantes Médicinales et Phytothérapie, 1987, 21 (2), 99-105.

(Scopus indexed; ISSN: 0032-0994)

 

Bisbenzylisoquinoline alkaloids from Abuta pahni

P. Duté, J.-F. Weber, A. Fournet, Ad. Cavé and J. Bruneton.

Phytochemistry, 1987, 26 (7), 2136-2137.

(Scopus indexed; IF2012 = 3.050; ISSN: 0031-9422; DOI: 10.1016/S0031-9422(00)81784-7)

 

Alkaloidal content of four Berberis species; structure of two new bisbenzyltetrahydroisoquinolines

J.-F. Weber, A.-M. Le Ray, J. Bruneton and A. Fournet.

Journal of Natural Products, 1989, 52 (1), 81-84.

(Scopus indexed; IF2012 = 3.285; ISSN: 0163-3864; DOI: 10.1021/np50061a010)

 

A new phytochemical survey of Malaysia -V- Preliminary screening and plant chemical studies

L.E. Teo, G. Pachiaper, K.C. Chan, A. Hamid, J.-F. Weber, J.R. Deverre, B. David, T. Sévenet.

Journal of Ethnopharmacology, 1990, 28 (1), 63-101.

(Scopus indexed, IF2012 = 2.755; ISSN: 0378-8741; DOI: 10.1016/0378-8741(90)90066-3)

 

Lepadiformine, a new cytotoxic alkaloid from Clavelina lepadiformis Müller

J.F. Biard, S. Guyot, C. Roussakis, J.F. Verbist, J. Vercauteren, J.-F. Weber and K. Boukef.

Tetrahedron Letters, 1994, 35 (17), 2691-2694.

(Scopus indexed, IF2012 = 2.397; ISSN: 0040-4039; DOI: 10.1016/S0040-4039(00)77007-9)

 

Heimiol A, a new dimeric stilbenoid from Neobalanocarpus heimii

J.-F.F. Weber, I. Abd. Wahab, A. Marzuki, N.F. Thomas, A. Abd. Kadir, A. Hamid A. Hadi, K. Awang, A. Abd. Latiff, H. Rashwan, P. Richomme and J. Delaunay.

Tetrahedron Letters, 2001, 42 (29), 4895-4897.

(Scopus indexed, IF2012 = 2.397; ISSN: 0040-4039; DOI: 10.1016/S0040-4039(01)00772-9)

 

Manganese triacetate oxidative lactonisation of electron-rich stilbenes possessing catechol and resorcinol substitution (resveratrol analogues)

N.F. Thomas, K.C. Lee, Thomas Paraidathathu, J.-F.F. Weber and K. Awang.

Tetrahedron Letters, 2002, 43 (17), 3151-3155.

(Scopus indexed, IF2012 = 2.397; ISSN: 0040-4039; DOI: 10.1016/S0040-4039(02)00484-7)

 

Tandem pericyclic reactions in a new FeCl3-promoted synthesis of catechol analogues of restrytisol C

N.F. Thomas, K.C. Lee, Thomas Paraidathathu, J.-F.F. Weber, K. Awang, D. Rondeau and P. Richomme.

Tetrahedron, 2002, 58 (36), 7201-7206.

(Scopus indexed, IF2012 = 2.803; ISSN: 0040-4020; DOI: 10.1016/S0040-4020(02)00798-6)

 

A tandem highly stereoselective FeCl3-promoted synthesis of a bisindoline: synthetic utility of radical cations in heterocyclic construction

N.F. Thomas, S.S. Velu, J.-F.F. Weber, K.C. Lee, A. Hamid. A. Hadi, P. Richomme, D. Rondeau, I. Noorbatcha and K. Awang.

Tetrahedron, 2004, 60 (51), 11733-11742.

(Scopus indexed, IF2012 = 2.803; ISSN: 0040-4020; DOI: 10.1016/j.tet.2004.10.002)

 

The subtle co-catalytic intervention of benzophenone in radical-mediated – An improved synthesis of 2-(3',4'-diphenyl)vindoline

N.F. Thomas, C. H. Kee, A. Ariffin, K. Awang, J.-F.F. Weber, C.G. Lim, M.R. Mukhtar and A. Hamid. A. Hadi

Heterocycles, 2008, 75 (5), 1097-1108.

(Scopus indexed, IF2012 = 1.077; ISSN 0385-5414)

 

Regio- and stereoselective biomimetic synthesis of oligostilbenoids dimers from resveratrol analogues: Influence of the solvent, oxidant and substitution

S.S. Velu, I. Buniyamin, K.C. Lee, F. Feroz, I. Noorbatcha, C.G. Lim, K. Awang, I. Abd. Wahab and J.-F.F. Weber.

Chemistry – A European Journal, 2008, 14 (36), 11376-11384.

(Scopus indexed, IF2012 = 5.831; ISSN: 1521-3765; DOI: 10.1002/chem.200801575)

 

A FeCl3-promoted highly atropodiastereoselective cascade reaction: Synthetic utility of radical cations in indolostilbene construction

K. Ahmad, N.F. Thomas, M.R. Mukhtar, I. Noorbatcha, J.-F.F. Weber, M.A. Nafiah, S.S. Velu, K. Takeya, H. Morita, C.G. Lim, A.H.A. Hadi and K. Awang

Tetrahedron, 2009, 65 (7), 1504-1516.

(Scopus indexed, IF2012 = 2.803; ISSN: 0040-4020; DOI: 10.1016/j.tet.2008.11.100)

 

N-{2-[2-(2,6-Dichloro-3,5-dimethoxyphenyl) ethenyl]phenyl}acetamide

K. Ahmad, K. Awang, N.F. Thomas, J.-F.F. Weber and S.W. Ng.

Acta Crystallographica, 2009, E65, o438.

(Scopus indexed, IF2011 = 0.347; ISSN: 1600-5368; DOI: 10.1107/S1600536809003250)                                                                                 

 

Alkaloids from the Malayan Hunteria zeylanica Gard

K. Awang, N.H. Ismail, S.S. Velu, N.F. Thomas, J.-F.F. Weber and A.H.A. Hadi

Malaysian Journal of Science, 2009, 28 (2), 205-208.

(Scopus indexed; IF2012 = 0.069; ISSN: 1394-3065)                                                                                                                                            

 

Antimicrobial and cytotoxic activities of Malaysian endophytes

K. Ramasamy, S.M. Lim, H. Abu Bakar, N. Ismail, M.S. Ismail, M.F. Ali, J.-F.F. Weber and A.L. J. Cole.

Phytotherapy Research, 2010, 24 (5), 640-643.

(Scopus indexed; IF2012 = 1.872.068; ISSN: 1099-1573;DOI: 10.1002/ptr.2891)                                                                                               

 

Challenges associated with the synthesis of unusual o-carboxamido stilbenes by Heck protocol: Intriguing substitutent effecs, their toxicological and chemopreventive implications.

C.H. Kee, A. Ariffin, K. Awang, K. Takeya, H. Morita, S.I Hussain, K.M. Chan, P.J.Wood, M.D. Threadgill, C.G. Lim, S.W. Ng, J.-F.F. Weber and N.F. Thomas.

Organic & Biomolecular Chemistry, 2010, 8 (24), 5646-5660.

(Scopus indexed; IF2012 = 3.568; ISSN: 1477-0520; DOI: 10.1039/c0ob00296h)                                                                                               

 

Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG2 and Chang liver cells: Implication for structure activity relationship

A.H. Hasiah, A.R. Ghazali, J.-F.F Weber, S.S. Velu, N.F. Thomas and S.H. Inayat Hussain.

Human & Experimental Toxicology, 2011, 30 (2), 138-144.

(Scopus indexed; IF2012 = 1.453; ISSN: 0960-3271; DOI: 10.1177/0960327110368739)

 

Phytochemical and cytotoxic investigations of Curcuma mangga rhizomes

S.N.A. Malek, G.S. Lee, S.L. Hong, H. Yaacob, N. Abdul Wahab, J.-F.F. Weber and S.A. Ali Shah

Molecules, 2011, 16 (6), 4539-4548.

(Scopus indexed; IF2012 = 2.428; ISSN: 1420-3049; DOI:10.3390/molecules16064539)                                                                                    

 

Synthesis and SAR study of prenylated xanthone analogues as Hela and MDA-MB-231 cancer cell inhibitors

C.K. Lim, L.-Y. Tho, C.H. Lim, Y.M. Lim, S.A. Ali Shah and J.-F.F. Weber.

Letters in Drug Design and Discovery, 2011, 8 (6), 523-528.

(Scopus indexed; IF2012 = 0.667; ISSN: 1570-1808; DOI: 10.2174/157018011795906820)                                                                               

 

Strategies and methods for the syntheses of natural oligomeric stilbenoids and analogues

S.S. Velu, N.F. Thomas and J.-F.F. Weber.

Current Organic Chemistry, 2012, 16 (5), 605-662. Special issue on polyphenol chemistry. Invited review article.

(Scopus indexed; IF2012 = 3.039; ISSN: 1385-2728; DOI: 10.2174/138527212799859390)                                                                               

 

3,5-Dibenzyloxy-4’-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells

H. Roslie, K.M. Chan, N.F. Rajab, S.S. Velu, S.A. Kadir, I. Bunyamin, J.-F.F. Weber, N.F.Thomas, A.B. Abd. Majeed, G. Myatt and S.H. Inayat-Hussain.

Journal of Toxicological Sciences, 2012, 37 (1), 13-21.

(Scopus indexed; IF2012 = 1.380; ISSN: 1880-3989; DOI: 10.1021/np300705p)                                                                                          

 

Synthesis of 1,3,6-trioxygenated prenylated xanthone derivatives as potential antitumor agents

C.K. Lim, L.-Y. Tho, Y.M. Lim, S.A. Ali Shah and J.-F.F. Weber

Letters in Organic Chemistry, 2012, 9 (8), 549-555.

(Scopus indexed; IF2012 = 0.667; ISSN: 1570-1786; DOI: 10.2174/157017812802850230)                                                                        

 

Regio- and stereocontrolled synthesis of oligostilbenoids: theoretical highlights at the supramolecular level

S.S. Velu, F. Di Meo, P. Trouillas, J.C. Sancho-Garcia and J.-F.F. Weber.

Journal of Natural Products, 2013, 76 (4), 538-546.

(Scopus indexed; IF2012 = 3.285; ISSN: 0163-3864; DOI: 10.1021/np300705p)                                                                                          

 

Design, synthesis, in vitro cytotoxicity evaluation and structure–activity relationship of goniothalamin analogs

M. Mohideen, S. Zulkepli, N.S. Nik-Salleh, Mohd Zulkefeli, J.-F.F. Weber and A.F.M. Motiur Rahman.

Archives of Pharmacal Research, 2013, 36 (7), 812-831; ib. 918 (Erratum).

(Scopus indexed; IF2012 = 1.538; ISSN: 0253-6269; DOI: 10.1007/s12272-013-0099-1)                                                                            

 

?-Stacked polyphenolic dimers: A case study using dispersion-corrected methods

I. Bayach, J.C. Sancho-García, F. Di Meo, J.-F.F. Weber and P. Trouillas.

Chemical Physics Letters, 2013, 578, 120-125.

(Scopus indexed; IF2012 = 2.145; ISSN: 0009-2614; DOI: 10.1016/j.cplett.2013.05.064)                                                                             

 

Time-dependent density functional theory study of UV/visible spectra of natural styrylpyrones

E.H. Anouar and J.-F.F. Weber

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 115, 675-682.

(Scopus indexed; IF2012 = 1.977; ISSN: 1386-1425; DOI: 10.1016/j.saa.2013.06.114)                                                                                

 

Diversity of endophytic bacteria in Malaysian plants as revealed by 16S rRNA encoding gene sequence based method of bacterial identification

C.Y. Loh, Y.Y. Tan, R. Rahim, J.-F.F. Weber and S.J. Bhore

Journal of Young Pharmacists, 2013, Available online 30 July 2013.

(Scopus indexed; ISSN: 0975-1483; DOI: 10.1016/j.jyp.2013.07.001)

 

Chemical and pharmacognostical characterization of two Malaysian plants both known as Ajisamat

T.A.S. Tengku Mohamad, H. Naz, R.S. Jalal, K. Hussin, M.R. Abd. Rahman, A. Adam and J.-F.F. Weber

Revista Brasileira de Farmacognosia, 2013, accepted.

(Scopus indexed; IF2012 = 0.676; ISSN: 0102-695X)

 

Patents

Compositions of polyphenols derivatives and their preparation

J. Vercauteren, J.F. Weber, J. Bignon and J.L. Bisson;

French Patent Application N° 93/07140, I.N.P.I. Paris, 14 June 1993; International Application PCT/Fr N° 94/00712, I.P.E.A. Munich, 14 June 1994.

 

Esters of polyhydroxylated aromatic compounds, their preparation and their applications

J. Vercauteren, L. Bahuet and J.F. Weber

French Patent Application N° 94/15420, I.N.P.I. Paris, 21 December 1994.

 

Bioactive compounds

Canterprise Limited, J.-F. Weber, Kalavathy Ramasamy, Hamidah Abu Bakar andAbu Bakar Abdul Majeed

International Application PCT/MY2009/000176, Australian Patent Office, 30 October 2009.

Our Address

Level 11, FF1 Building,
Faculty of Pharmacy, UiTM Puncak Alam Campus
Bandar Puncak Alam
Selangor
42300
MALAYSIA

Tel: +603-32584645
Fax: +603-32584602

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